Secondary erythrocytosis due to a cerebellar hemangioblastoma: demonstration of erythropoietin mRNA in the tumor
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Secondary erythrocytosis due to a cerebellar hemangioblastoma: demonstration of erythropoietin mRNA in the tumor.
Cerebellar hemangioblastoma is a rare cause of secondary erythrocytosis. Although the erythrocytosis is a result of erythropoietin (Ep) stimulation, direct evidence of Ep synthesis by the tumor has been lacking. In an erythrocytotic patient with a cerebellar hemangioblastoma we found elevated levels of Ep in the tumor cyst fluid and for the first time demonstrated Ep mRNA in the tumor by Northe...
متن کاملSecondary Erythrocytosis Due To a Cerebellar Hemangioblastoma: Demonstration of Erythropoietin mRNA in the Tumor
RYTHROPOIETIN (Ep) is a glycoprotein hormone E produced mainly by the kidney and is the principle regulator of erythropoiesis.' The level of Ep is normally tightly controlled and helps to maintain a relatively constant red blood cell (RBC) mass.' Occasionally, abnormal production of Ep results in secondary erythrocytosis. Secondary erythrocytosis has been reported in a variety of tumors includi...
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15 صفحه اولAutosomal Dominant familial erythrocytosis due to autonomous erythropoietin production.
A family is described in which four members spanning three consecutive generations have erythrocytosis associated with a normal hemoglobin oxygen affinity. When bone marrow from one affected family member was cultured in vitro, erythroid colonies formed only when erythropoietin was added to the culture. Serum erythropoietin, measured by radioimmunoassay, was significantly elevated above normal ...
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ژورنال
عنوان ژورنال: Blood
سال: 1991
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v78.3.599.bloodjournal783599